The terms endemic, epidemic and pandemic are often confused, but in epidemiology they have precise meanings describing disease spread, not danger.
An endemic disease occurs regularly in certain regions with a relatively constant number of cases, such as malaria affecting 300 million people annually in the tropics.
An epidemic is an unusually frequent occurrence of a disease in a specific region over a limited period, often due to virus mutation or introduction to a new area.
A pandemic is an epidemic that spreads across countries and continents, requiring cooperation among health systems for control.
Pandemics are usually caused by new pathogens or viruses, such as zoonoses transmitted from animals to humans.
An example of an epidemic is smallpox introduced to the Americas in the 16th century, killing up to 90% of the indigenous population.