• A study published in PNAS showed that blocking the enzyme PTP1B in a mouse model of Alzheimer’s disease improves microglial function and reduces amyloid plaques.
  • Alzheimer’s disease is increasingly viewed as a metabolic disorder linked to diabetes, obesity, and inflammation.
  • About 45% of dementia cases could be prevented or delayed by better management of modifiable risk factors such as diabetes and hypertension.
  • PTP1B is an enzyme that regulates insulin and leptin signaling, already known in the context of metabolic diseases.
  • Microglia, the brain’s immune cells, are key to clearing amyloid but become dysfunctional in Alzheimer’s.

Sources & Links